Events to commemorate the 75th anniversary of the service will be attended by NHS employees from across the South East.
Both a service at Westminster Abbey and a reception at 10 Downing Street will be attended by them.
The Dartford Crossing and Brighton Pier, among other locations and landmarks, will have blue lighting.
Even though experts have expressed concern about the NHS' long-term viability, health minister Maria Caulfield predicted that it would still be "thriving" in 25 years.
The anniversary falls during a time when NHS employees have been engaging in industrial action over pay disputes.
I've worked in the NHS for more than 30 of its 75 years, according to Ms. Caulfield, a nurse and the Lewes MP. I've witnessed enormous change, and throughout my career working for the NHS, I believe people have always been extremely pessimistic about its future. ".
I have no doubt the NHS will be thriving in 25 years, she declared. ".
The NHS is based on the millions of dedicated employees and volunteers who have proven their ability to innovate and adapt to the new challenges we face in providing care for successive generations, according to Anne Eden, regional director for NHS South East.
I want to take this opportunity to thank NHS staff across the South East for all that they continue to do as we celebrate the NHS' 75th birthday and speculate about what the next 75 years may bring. ".
The Bluewater shopping center, Brighton Pier, Hever Castle, the QE2 bridge in Dartford, and Rochester Cathedral and Castle are among the locations that will have blue lighting.
"Seeing the city light up blue is a good reminder of how important it is to all of our lives, and long may it continue," said Bruno De Oliveira, chair of the Brighton and Hove Health and Wellbeing Board.