Due to staff training, routine doctor appointments won't be offered in the future, according to Manx Care.
Only repeat prescriptions, future appointments, and test results are available to residents at GP offices between 13:00 and 18:00 BST.
The "transformation of primary care services" would be made known to general practitioners, according to a spokeswoman.
She also advised anyone in need of medical attention right away to call their surgery to speak with an on-call doctor.
As for choosing wisely when seeking appropriate medical care and guidance during the time, the healthcare provider has advised residents to do so.
Other medical services include the Minor Injuries and Illnesses Unit at Ramsey Cottage Hospital, the Minor Eye Conditions Scheme at Specsavers, and the Minor Ails Scheme run by neighborhood pharmacies on the island.
Patients who experience dental emergencies should call their own dentist; those who do not currently have a dentist registered with them can use the community dental service. .
But according to Manx Care, anyone who thinks they have a life-threatening emergency should still "dial 999 and ask for the ambulance service.".
On Wednesday, regular GP appointments should resume throughout the island.
A morning session led by the patient transfers team and MCALS (Manx Care Advice and Liaison Service) is open to residents who will be traveling off-island for medical treatment.
Information and support about travel and care will be available at the drop-in session, which will take place at Ramsey Town Hall between 10:00 and 12:00.