Brookeborough and Tempo Surgery's doctors have given notice that they are terminating their employment.
The third returned general practitioner contract in County Fermanagh since last summer, this is the 13th such contract in Northern Ireland over the past year.
According to BBC News NI, the Western Trust will now take over the practice and its 8,000 patients.
The practice is having problems, such as with getting new doctors to come to the rural area.
BBC News NI is aware that inadequate infrastructure and a lack of investment have also been factors.
In June 2022, Dromore and Trillick surgeries returned their contracts, and in December, Maple Healthcare in Lisnaskea did the same.
In the past six months, County Fermanagh has received three contracts that have been returned.
One doctor told me that "no new blood" was entering the system.
In a rural area where doctors are always in demand, this means that no new doctors will be moving to the area to take over these extremely busy practices.
The doctors I spoke with last night and this morning agree that a significant issue is the lack of leadership. There is nobody they can turn to.
In Northern Ireland, neither an executive nor a health minister exist.
We don't currently have a leader, and we're not really sure who is in charge of the health system.
In Northern Ireland, this is the 13th contract that has been returned, but we are aware that it won't be the last.