Syria's military says five people have died after what it alleged were Israeli missiles hit the capital Damascus and surrounding areas on Sunday.
Officials said a building was hit in the central Kafr Sousa neighbourhood, killing four civilians and one soldier.
The densely populated district is home to a large, heavily guarded security complex.
When contacted by the Reuters news agency, Israel's military declined to comment on the strike.
Israel frequently attacks Hezbollah and Iranian-linked targets in Syria, but it rarely receives recognition for these attacks. However, attacks on residential areas are rare.
Sunday's attack was the first since a devastating 7.8 magnitude earthquake struck the north-west of the country, as well as parts of neighbouring Turkey, 12 days ago.
Senior government officials and security organizations as well as civilians who reside in residential buildings can be found in the Kafr Sousa area.
Several homes in neighborhoods near Damascus and other nearby areas were damaged by the strike, which occurred at 00:22 local time (21:22 GMT), according to Syrian officials.
The country's defence ministry said the rockets were launched from the Golan Heights, a rocky plateau south-west of Damascus which was annexed by Israel in 1981.
15 people, including civilians, were killed, according to the Syrian Observatory for Human Rights in London.
"The strike on Sunday is the deadliest Israeli attack in the Syrian capital," said Rami Abdel Rahman, head of the observatory.
It occurs more than a month after an Israeli strike, which the Syrian army claims targeted the international airport in Damascus and killed four people, including two soldiers.
Israel has previously acknowledged that it targets the bases of militant groups loyal to Iran.
The two countries are arch-foes and in recent years have been engaged in what has been described as a "shadow war" of unclaimed attacks on each other's assets, infrastructure and nationals.