It has been mandated that employees of the European Commission take TikTok off of their personal phones and company-issued gadgets.
The commission stated that the goal of the measure was to "protect data and improve cybersecurity.".
There have been claims made against TikTok, which is owned by the Chinese company ByteDance, that it collects user data and gives it to the Chinese government.
TikTok claims that its business model is the same as that of other social media.
Thierry Breton, the industry chief for the European Union (EU), declined to give more information at a news conference, but stated that the executive of the union is very focused on cybersecurity.
Additionally, the ban prevents employees of the European Commission from using TikTok on personal devices that have official apps installed.
Approximately 32,000 permanent and contract employees, according to the commission.
The app must be taken down as soon as possible, but no later than March 15.
The corporate apps, such as the commission email and Skype for Business, won't be accessible to those who don't comply by the deadline.
The decision of the commission, according to TikTok, was based on false assumptions about its platform.
A spokesperson expressed disappointment with the choice, calling it misguided and built on fundamental misunderstandings.
In the past year, TikTok has admitted that some employees in China have access to user data from Europe.
ByteDance, the parent company of TikTok, has recently come under increased Western scrutiny due to concerns over Beijing's access to user data.
Due to concerns about national security, the US government last year banned TikTok on federally owned devices.
The US is concerned that the Chinese government may use TikTok to gain access to those devices and the data of US users.
The Dutch government reportedly advised public servants to avoid the app last month due to similar worries.
In a recent interview with Sky News, Alicia Kerns, MP and chair of the Foreign Affairs Select Committee in the UK, urged users to delete the app.
TikTok has expanded quickly and, according to analytics company Sensor Tower Data, was the first non-Meta app to reach three billion downloads worldwide.
The EU officials cautioned TikTok to ensure the safety of European users' data and added that it had a long way to go to regain their trust during discussions with the social media service's chief executive Shou Zi Chew in Brussels in January.
An EU spokesman at the time reported that he insisted the company was developing a "robust" system for handling Europeans' data in Europe.
To allay Washington's worries, TikTok has also promised to store the data of US users there.